Analyzing the major tuberculosis epidemiological indices in West Siberia in 1991-1995 has indicated that the epidemic situation in the region tends to catastrophically deteriorate. Its general morbidity doubled, amounting to 83.5 per 100,000 inhabitants. Among children, there was a rise in morbidity rates from 18.5 per 100,000 in 1993 ot 21.3 in 1995. This index was 33.1% for children aged 0 to 4 years. Morbidity in adolescents increased by 30.2%. Deaths from tuberculosis and its sequelae showed a 1.7-fold increase, accounting for 16.0 per 100,000 inhabitants. During the first year, the deceased increased in number from 9.1% in 1991 to 17.3% in 1996.