The glaucous gull (Larus hyperboreus) is one of the largest avian top predators in the Arctic. High levels of persistent organic pollutants (POPs) and their metabolites have been detected in the glaucous gull, and several studies indicate that high levels of different POPs can contribute to detrimental effects. The mechanism behind these disruptions could be that chemicals interfere with the endocrine system. Thyroid hormones (THs) are important for thermogenesis, reproduction, growth and differentiation. They are transported in the circulation system of glaucous gull mainly bound to the transport proteins globulin, albumin and transthyretin (TTR). The aim of this study was to use molecular modeling to construct a homology model of the TTR in glaucous gull and to dock several well-known and new emerging POPs in the models to predict the binding affinity of POPs to the TH binding site in glaucous gull TTR...