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Rigorous tests of gene-environment interactions in a lab study of the oxytocin receptor gene (OXTR), alcohol exposure, and aggression.
https://arctichealth.org/en/permalink/ahliterature285891
Source
Am J Med Genet B Neuropsychiatr Genet. 2016 Jul;171(5):589-602
Publication Type
Article
Date
Jul-2016
More detail
Author
Devon LoParo
Ada Johansson
Hasse Walum
Lars Westberg
Pekka Santtila
Irwin Waldman
Source
Am J Med Genet B Neuropsychiatr Genet. 2016 Jul;171(5):589-602
Date
Jul-2016
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aggression - drug effects
Alcohol Drinking - psychology
Alleles
Ethanol - adverse effects
Finland
Gene-Environment Interaction
Genetic Variation - genetics
Haplotypes
Humans
Male
Oxytocin - genetics
Polymorphism, Single Nucleotide - genetics
Receptors, Oxytocin - genetics - metabolism - physiology
Young Adult
Abstract
Naturalistic studies of gene-environment interactions (G X E) have been plagued by several limitations, including difficulty isolating specific environmental risk factors from other correlated aspects of the environment, gene-environment correlation (rGE ), and the use of a single genetic variant to represent the influence of a gene. We present results from 235 Finnish young men in two lab studies of aggression and alcohol challenge that attempt to redress these limitations of the extant G X E literature. Specifically, we use a latent variable modeling approach in an attempt to more fully account for genetic variation across the oxytocin receptor gene (OXTR) and to robustly test its main effects on aggression and its interaction with alcohol exposure. We also modeled aggression as a latent variable comprising various indices, including the average and maximum levels of aggression, the earliest trial on which aggression was expressed, and the proportion of trials on which the minimum and maximum levels of aggression were expressed. The best fitting model for the genetic variation across OXTR included six factors derived from an exploratory factor analysis, roughly corresponding to six haplotype blocks. Aggression levels were higher on trials in which participants were administered alcohol, won, or were provoked. There was a significant main effect of OXTR on aggression across studies after controlling for covariates. The interaction of OXTR and alcohol was also significant across studies, such that OXTR had stronger effects on aggression in the alcohol administration condition. © 2015 Wiley Periodicals, Inc.
PubMed ID
26250573
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