Sanitary, hygienic, clinicostatistical and immunologic study of 680 female workers engaged in animal husbandry was carried out. For the assessment of their immunologic status the study was designed to analyze the content of circulating immune complexes, hemolytic activity of the complement system and its components, basic immunoglobulin classes (A, M, G, E) and R-proteins. It was demonstrated that female cattle breeders had higher rate of communicable diseases developing into chronic forms and periodically characterized by acute conditions. The female workers engaged in animal husbandry for a long period of time had a disbalance of the above indicators and significant body allergization.