It has been shown that men living in the Extreme North experience the tension of thermoregulation and its effectors. The main systems that maintain thermal balance of the body are the cardiovascular system and external respiration taking an active part in the processes of physical and chemical thermoregulation. The double load of the key system leads to non-economic and rapid spending of the functional reserves and risk of early development of disadaptation phenomena. The authors worded a scientific concept of the systemic organization in the maintenance of temperature constancy of the internal medium of man in the Extreme North, which permits estimating the degree of the participation of the subordinated subsystems in thermoregulatory processes.