The structural and functional responses of lymph nodes to environmental influences have common stereotypic features; however, they can vary with the nature of an influencing factor and the functional specialization of the lymph node. In this view, the morphological and functional status of lymph nodes can be regarded as markers of environmental impact on the lymphatic system. Approaches to correcting blood and lymph circulation have been developed via combined exposure of the body's internal environment to sorbent therapy, balneological procedures at the Siberian resorts, biological flavonoids, and derivatives of Siberian raw plant materials.