Parameters characterizing public health activities in Chelyabinsk are analyzed. Time course of volume parameters characterizing the activities of multi-discipline hospitals and analogous parameters for the whole city demonstrate their relationships and necessitate optimization of management of primarily large multi-discipline institutions. Among the elements of this optimization are planning of volume parameters of the treatment-and-prophylaxis institutions in accordance with the municipal order, revision of indications for hospitalization, control of validity of hospitalization, and improvement of managing technologies in outpatient clinics.