One of the effective ways of normalization of micronutrients deficiency (vitamins, mineral substances etc.) for children and adult population--use of the specialized foodstuffs enriched with essential food substances in a daily diet is considered in the paper. On the basis of the analysis of foreign experience and the data accumulated as a result of performance of some state scientific and technical programs and the major projects of the Ministry of Science, Industry and Technologies of the Russian Federation, the basic scientific principles of enrichment of foodstuffs with vitamins and mineral substances are considered. In view of these principles the wide range of products of preventive purpose is developed: bakery, confectionery products, grain concentrates, dry mixes for preparation of the beverages, enriched with vitamins and some mineral substances (iron, calcium, magnesium). Large-scale clinical approbation of the developed products on various groups of the population (children of preschool and school age, pregnant women, workers of hard trades, patients with hypertonic disease, diabetes), has shown their efficiency both in the improvement of the vitamin status of surveyed and some therapeutic parameters. Circulars, instruction on application, methodical recommendations are developed and authorized.