Tuberculosis is an urgent problem in the North-Western Federal Okrug of the Russian Federation. In the past 5 years, the tuberculosis epidemic situation in the okrug has remained to be of strain despite the fact that the spread of tuberculous infection in the North-West is less than in whole Russia. The proper financing of tuberculosis-controlling measures, the solution of a staff-associated problem, and the improvement of the logistic base of a tuberculosis service facility are required to stabilize the tuberculosis situation.