Different variants of teaching organization at high school have been studied on the basis of a comparative analysis. The 10th-form pupils of specialized classes have been established to have a lower level of mental performance than those of the same age from general educational classes. This is associated with the drastic increase in a weekly summary educational load as compared with that in a ninth form, which was characteristic of the pupils of specialized classes; their educational load is increased by 8.5 hours whereas that is by 2.5 hours in those of educational classes. The adaptation of the pupils of specialized classes to new specialized educational conditions is completed by the 11th form, as suggested by the positive changes in their mental performance. The study of different models of specialized education organization has revealed that a multispecialized model that can individualize an academic process to a greater extent is hygienically most favorable. Recommendations have been developed for the hygienic optimization of an academic process at high school.