The occupational pattern and clinical characteristics of 587 medical workers detected as having tuberculosis over 13 years in the Krasnoyarsk Territory are analyzed. The distinctive features of the pattern of clinical forms of a tuberculous process and its characteristics have been identified in the medical workers as compared with nonmedical workers and regional differences have been also revealed. The reasons are shown for higher tuberculosis morbidity in physicians. There is evidence for the leading role of exogenous superinfection and its nosocomial pattern in the development of tuberculosis in medical workers. Pitfalls associated with the fact that the administrators of therapeutic-and-prophylactic and medical facilities exercise lax control over regular fluorographic studies of medical workers have been established in the organization of active tuberculosis detection. The findings are as a basis for developing a new guideline for the detection and prevention of tuberculosis in medical workers under the established epidemic situation.