To study the effects of menopausal hormone therapy (HT) on health-related quality of life in women after breast cancer.
In the Stockholm trial, breast cancer survivors were randomized to HT (estradiol and progestogen) or to a control group (no treatment). A subgroup of 75 women was studied (38 with HT, 37 controls). Fifty patients were on concomitant tamoxifen. Patients completed three questionnaires (EORTC QLQ C-30, EORTC QLQ-BR 23 and the Hospital Anxiety and Depression Scale (HADS)) during 1 year of treatment.
A significant group-by-time interaction was found for improvement of insomnia in the HT group (p?