Nosocomial pyoseptic infections are one of the topical problems of the practical activity of surgical hospitals. Their occurrence is due to the influence of risk factors associated with patients' condition, a therapeutic and diagnostic process, and the hospital environment. A package of measures for the prevention of infectious complications comprises the sanitary-and-antiepidemic measures, its one component being sanitary-and-hygienic ones. The diagnosis of the epidemiological features of nosocomial infections allows the basic and additional sanitary-and- hygienic measures to be identified, differentiated, and rationalized depending on the categories of patients and the types of units with varying morbidity rates.