Department of Pediatrics, Division of Pediatric Nephrology, Children's Hospital, London Health Sciences Centre, University of Western Ontario, London, Ontario, N6A 5W9 Canada. guido.filler@lhsc.on.ca
The diagnostic accuracy of cystatin C estimated GFR (eGFR) by various cystatin C equations have varied in different studies. We hypothesized that the GFR level of enrolled patients affects the diagnostic accuracy of a cystatin C equation.
We analyzed 240 consecutively enrolled children at a single Canadian center in a prospective and cross-sectional study. Cystatin C was analyzed with nephelometry, and cystatin C eGFR was estimated by the equations validated in children. GFR was measured by technetium-99m-diethylene-triamine penta-acetic acid (??m)Tc DTPA).
We compared various cystatin C equations across GFR strata