Recently, there has been a growing concern in clinical settings regarding the use of evidence-based best practices. We have noted the appearance of various training activities and resources that can be used by oncology nurses. Using a time series design, this study highlights that the actual utilization of evidence in practice remains unchanged after an intervention of a formal PowerPoint presentation of evidence on symptom management in oncology, and the distribution of reference folders with research results to nurses. It emerges that very few nurses are interested and that the nurses who use evidence are those who do it as part of their functions (staff manager, clinicians). Recommendations for practice, education and research are suggested.