Higher anticholinergic drug scale (ADS) scores are associated with peripheral but not cognitive markers of cholinergic blockade. Cross sectional data from 21 Norwegian nursing homes.
This study evaluated a presumed gradual decline in cognitive function in nursing home residents when the anticholinergic drug scale (ADS) score increased above 3.
The study population was recruited from 21 nursing homes in Norway. Criteria for inclusion were ADS score?=?3 and no severe dementia, defined as Clinical Dementia Rating (CDR) score 0.10), but in vivo (mouth dryness) and in vitro (SAA) measures of peripheral anticholinergic activity were significantly higher in patients with an ADS score =6 (P
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