In conjunction with the Mars-500 project, 17 male residents (25-46 y.o.) of the North of Russia (62 degrees 40'N) were examined monthly using hard- and software EKOSAN-2007. In the period of June, 2010 through to November, 2011 they visited a standard laboratory to go through comprehensive anthropophysiometric, psychophysiological and physiological investigations at rest and combined with exercise, standing and cold tests aimed at tracking the seasonal responses of the body functional parameters. The larger part of group-average psychomotor, breathing and circulation measurements as well as heart rate variability did not exhibit statistically significant differences between months or seasons. Reliable seasonal variations were documented in the life index, body and cutaneous temperature, myocardium index and regulatory systems activity. A correlation between environmental and some body functional parameters was established. In the course of the multi-month monitoring there were periods when essentially healthy people were diagnosed as prenosologic and even premorbid. Some findings in the functioning of male northerner's organism are clearly attributable to living in the high-altitude area.