[Benz(a)pyrene antibodies are a marker of carcinogenic load in coal-processing workers]

https://arctichealth.org/en/permalink/ahliterature96898
Source
Gig Sanit. 2010 Mar-Apr;(2):53-6
Publication Type
Article
Author
A N Glushkov
E G Poleniuk
S A Mun
S A Larin
S F Zinchuk
Source
Gig Sanit. 2010 Mar-Apr;(2):53-6
Language
Russian
Publication Type
Article
Keywords
Antibodies - blood - immunology
Benzo(a)pyrene - metabolism
Carcinogens
Coal Mining
Female
Humans
Immunoenzyme Techniques
Male
Neoplasms - blood - immunology
Occupational Exposure - adverse effects
Siberia
Tumor Markers, Biological - blood - immunology
Abstract
The authors studied benz(a)pyrene-specific secretory and serum antibody ratios (Ka) in 249 workers of the Kemerovo Power Station, by applying their modified enzyme immunoassay technique. There were 37 (20.5%) and 4 (5.8%) cases with Ka >2 at the preset immunoassay parameters of the 180 and 69 workers of mainline production and auxiliary units, respectively. A Ka value of >2 was found in 35 (21.6%) of the 162 males and only in 6 (6.9%) of the 87 females of the whole sample, in 29 (26.1%) of the 111 smokers and in 12 (8.7%) of the 138 non-smokers. The technique is proposed to study specific immune reactions and exposure to carcinogens primarily in workers of the enterprises processing coal and other types of fuel.
PubMed ID
20491270 View in PubMed
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