Prevalence of high alcohol and benzodiazepine consumption in sleep apnea patients studied with blood and urine tests.

https://arctichealth.org/en/permalink/ahliterature9267
Source
Acta Otolaryngol. 2004 Dec;124(10):1187-90
Publication Type
Article
Date
Dec-2004
Author
Pia Nerfeldt
Peter Graf
Stefan Borg
Danielle Friberg
Author Affiliation
Department of Otorhinolaryngology, Karolinska Institute, Stockholm, Sweden. pia.nerfeldt@kus.se
Source
Acta Otolaryngol. 2004 Dec;124(10):1187-90
Date
Dec-2004
Language
English
Publication Type
Article
Keywords
Adult
Aged
Alcoholism - complications - diagnosis
Benzodiazepines - urine
Biological Markers - blood
Female
Humans
Hydroxytryptophol - blood
Male
Middle Aged
Sleep Apnea, Obstructive - etiology
Substance-Related Disorders - complications - diagnosis
Transferrin - analogs & derivatives - analysis
Abstract
OBJECTIVE: To evaluate the prevalence of alcoholism and benzodiazepine abuse among patients with obstructive sleep apnea syndrome (OSAS). Such abuse may aggravate the tendency to apneas, especially in patients with OSAS. MATERIAL AND METHODS: The study included 98 consecutive OSAS patients. Two patients dropped out; blood samples could not be obtained from two other patients and a urine sample could not be obtained from one. Blood and urine samples were examined for carbohydrate-deficient transferrin (CDT) and 5-hydroxytryptophol (5-HTOL), markers of excess alcohol intake, and urine-benzodiazepines (u-Benz), a marker of drug abuse. Patients with positive screening tests were offered therapy for their abuse. RESULTS: The CDT test was positive in 8/94 patients (8.5%), the 5-HTOL test in 6/95 (6.3%) and the u-Benz test in 3/95 (3.2%). CONCLUSIONS: Our findings correlate well with current views concerning alcohol and drug abuse in Sweden, and do not indicate that the frequency of such abuse is higher among OSAS patients. It should be noted that none of the patients who screened positive in the laboratory tests admitted to being alcohol or drug abusers when they consulted their physician. We recommend screening all OSAS patients for alcohol abuse using not only a questionnaire but also a laboratory test such as the CDT test.
PubMed ID
15768816 View in PubMed
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