FOXA transcription factors determine the amplitude of glucocorticoid induction of tyrosine aminotransferase in mice.

https://arctichealth.org/en/permalink/ahliterature92613
Source
Bull Exp Biol Med. 2007 Nov;144(5):722-4
Publication Type
Article
Date
Nov-2007
Author
Bryzgalov L O
Ershov N I
Ilnitskaya S I
Author Affiliation
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk. leon_l@ngs.ru
Source
Bull Exp Biol Med. 2007 Nov;144(5):722-4
Date
Nov-2007
Language
English
Publication Type
Article
Keywords
Animals
Enzyme Activation - drug effects
Forkhead Transcription Factors - metabolism
Glucocorticoids - pharmacology
Liver - drug effects - metabolism - pathology
Liver Neoplasms - chemically induced - metabolism
Methyldimethylaminoazobenzene
Mice
Mice, Inbred ICR
Protein Binding - drug effects
Time Factors
Tyrosine Transaminase - metabolism
o-Aminoazotoluene
Abstract
o-Aminoazotoluene was more potent than 3'-methyl-4-dimethylaminoazobenzene in modulating glucocorticoid induction of tyrosine aminotransferase and DNA-binding activity of FOXA (HNF3) in 12-day-old ICR mice. In adult animals, induction of tyrosine aminotransferase and FOXA activity were modulated by o-aminoazotoluene, while 3'-methyl-4-dimethylaminoazobenzene was ineffective. Our results suggest that FOXA proteins determine glucocorticoid induction of tyrosine aminotransferase in mice (similarly to rats).
PubMed ID
18683506 View in PubMed
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