[The effect of alpha-adrenoblockaders on the lipid complex of the myocardium, liver and erythrocytes in dogs with pulmonary heart failure]

https://arctichealth.org/en/permalink/ahliterature54738
Source
Fiziol Zh. 1995 Sep-Dec;41(5-6):80-3
Publication Type
Article
Author
S B Frantsuzova
L L Arshinnikova
T S Briuzhina
E Ia Kravchenko
Source
Fiziol Zh. 1995 Sep-Dec;41(5-6):80-3
Language
Ukrainian
Publication Type
Article
Keywords
Adrenergic alpha-Antagonists - pharmacology - therapeutic use
Animals
Comparative Study
Dogs
Drug Evaluation, Preclinical
English Abstract
Erythrocytes - drug effects - metabolism
Fatty Acids - metabolism
Female
Heart - drug effects
Lipid Metabolism
Liver - drug effects - metabolism
Male
Myocardium - metabolism
Prazosin - pharmacology - therapeutic use
Pulmonary Heart Disease - drug therapy - metabolism
Tropanes - pharmacology - therapeutic use
Abstract
Fatty acid spectrum of phospholipids and free cholesterol level in the myocardium, liver and erythrocytes were studied in dogs with the experimental lung-heart insufficiency (LHI). The content of polyunsaturated fatty acids of phospholipids in erythrocytes from peripheric blood and in free cholesterol level (2-3 times) in myocardium, liver and erythrocytes of dogs under investigated conditions decreased. It is shown that pharmacotherapy with alpha-adrenoblockers (thropaphen and prasozin) has led to the normalization of disturbances of the erythrocytic lipid complex and had caused inhibition of peroxidase reactions in the myocardium and liver of the dogs with LHI.
PubMed ID
9026398 View in PubMed
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