Ventilatory phenotypes among four strains of adult rats.

https://arctichealth.org/en/permalink/ahliterature49800
Source
J Appl Physiol. 2002 Sep;93(3):974-83
Publication Type
Article
Date
Sep-2002
Author
Matthew R Hodges
Hubert V Forster
Paula E Papanek
Melinda R Dwinell
Genevieve E Hogan
Author Affiliation
Department of Physiology, Medical College of Wisconsin, Wisconsin 53226, USA.
Source
J Appl Physiol. 2002 Sep;93(3):974-83
Date
Sep-2002
Language
English
Publication Type
Article
Keywords
Animals
Anoxia - physiopathology
Female
Hypercapnia - physiopathology
Male
Motor Activity - physiology
Phenotype
Rats
Rats, Inbred Strains - physiology
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Respiration
Respiratory physiology
Sex Characteristics
Species Specificity
Abstract
Our purpose in this study was to identify different ventilatory phenotypes among four different strains of rats. We examined 114 rats from three in-house, inbred strains and one outbred strain: Brown Norway (BN; n = 26), Dahl salt-sensitive (n = 24), Fawn-hooded Hypertensive (FHH: n = 27), and outbred Sprague-Dawley rats (SD; n = 37). We measured eupneic (room air) breathing and the ventilatory responses to hypoxia (12% O(2)-88% N(2)), hypercapnia (7% CO(2)), and two levels of submaximal exercise. Primary strain differences were between BN and the other strains. BN rats had a relatively attenuated ventilatory response to CO(2) (P 0.05), indicating that the metabolic rate during hypoxia decreased more in BN rats than in other strains. Another strain difference was in the frequency and timing components of augmented breaths, where FHH rats frequently differed from the other strains, and the BN rats had the longest expiratory time of the augmented breaths (probably secondary to the blunted CO(2) sensitivity). These strain differences not only provide insight into physiological mechanisms but also indicate traits (such as CO(2) sensitivity) that are genetically regulated. Finally, the data establish a foundation for physiological genomic studies aimed at elucidating the genetics of these ventilatory control mechanisms.
PubMed ID
12183493 View in PubMed
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