Prediction of the growth response of short prepubertal children treated with growth hormone. Swedish Paediatric Study Group for GH treatment.

https://arctichealth.org/en/permalink/ahliterature35512
Source
Acta Paediatr. 1995 Jan;84(1):51-7
Publication Type
Article
Date
Jan-1995
Author
B. Kriström
J. Karlberg
K. Albertsson-Wikland
Author Affiliation
Department of Paediatrics, University of Umeå, Sweden.
Source
Acta Paediatr. 1995 Jan;84(1):51-7
Date
Jan-1995
Language
English
Publication Type
Article
Keywords
Adolescent
Arginine - diagnostic use
Body Height - drug effects
Child
Child, Preschool
Female
Growth - drug effects
Growth Disorders - blood - drug therapy - physiopathology
Growth Hormone - blood - therapeutic use
Humans
Insulin - diagnostic use
Male
Predictive value of tests
Puberty
Regression Analysis
Research Support, Non-U.S. Gov't
Sweden
Abstract
The aim of this study was to identify predictors of the growth response to growth hormone (GH) during the first 2 years of GH treatment, using auxological data and the maximum GH response (GHmax) to provocation tests. The patients were 169 prepubertal short children (27F, 142M), with Gmax values ranging from 0 to 65 mU/l. Their mean age (+/- SD) was 8.3 +/- 2.4 years (range 3-13 years), mean height SDS -3.0 +/- 0.7 (range -1.5 to -6.0 SDS) and mean pretreatment height velocity was normal (+/- 0.0 SDS) (range -1.6 to +0.9 SDS). The increase in height SDS during the first 2 years of GH treatment (0.1 U/kg/day) varied from 0.10 to 3.75 SDS, with younger children having a better growth response. Individual growth responses correlated (p
PubMed ID
7734899 View in PubMed
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