Lissodendoric Acids A and B, Manzamine-Related Alkaloids from the Far Eastern Sponge Lissodendoryx florida.

https://arctichealth.org/en/permalink/ahliterature285792
Source
Org Lett. 2017 Oct 06;19(19):5320-5323
Publication Type
Article
Date
Oct-06-2017
Author
Ekaterina G Lyakhova
Sophia A Kolesnikova
Anatoly I Kalinovsky
Dmitrii V Berdyshev
Evgeny A Pislyagin
Aleksandra S Kuzmich
Roman S Popov
Pavel S Dmitrenok
Tatyana N Makarieva
Valentin A Stonik
Source
Org Lett. 2017 Oct 06;19(19):5320-5323
Date
Oct-06-2017
Language
English
Publication Type
Article
Abstract
The first representatives of a new group of manzamine-related alkaloids with a previously unknown skeletal systems, namely, lissodendoric acids A (1) and B (2), were isolated from the sponge Lissodendoryx florida collected from the Sea of Okhotsk. The structures and absolute configurations have been elucidated by extensive spectroscopic analysis together with chemical transformations and quantum-chemical modeling. The lissodendoric acids show a potent capability to decrease the production of reactive oxygen species in neuroblastoma Neuro 2a and somewhat increase the survival of these cells upon treatment with 6-hydroxydopamine (an in vitro antiparkinson biotest).
PubMed ID
28933163 View in PubMed
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