Branched-chain and aromatic amino acids in relation to behavioral problems among young Inuit from Nunavik, Canada: a cohort study.

https://arctichealth.org/en/permalink/ahliterature282388
Source
Pediatr Res. 2017 May 09;
Publication Type
Article
Date
May-09-2017
Author
Audray St-Jean
Salma Meziou
Cynthia Roy
Pierre Ayotte
Gina Muckle
Michel Lucas
Source
Pediatr Res. 2017 May 09;
Date
May-09-2017
Language
English
Publication Type
Article
Abstract
BACKGROUNDObesity and insulin resistance are linked with mood disorders, and elevated concentrations of branched-chain (BCAAs) and aromatic amino acids (AAAs). Our study aimed to prospectively assess the relationship between childhood plasma BCAAs and AAAs and behavioral problems in young Inuit from Nunavik.METHODSWe analyzed data on 181 children (mean age 11.4 years at baseline) involved in the Nunavik Child Development Study. Plasma BCAA and AAA concentrations were measured in childhood (2005-2010). BCAA/AAA tertiles - the ratio of total BCAAs to AAAs-were considered as a surrogate categorical independent variable. Behavioral problems were assessed with the Youth Self-Report (YSR) from the Child Behavior Checklist about 7 years later during adolescence (2013-2016). ANOVA ascertained relationships between BCAA/AAA tertiles and YSR outcomes.RESULTSAscending BCAA/AAA tertiles were positively associated (Ptrend
PubMed ID
28486439 View in PubMed
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