Differences in survival for patients with familial and sporadic cancer.

https://arctichealth.org/en/permalink/ahliterature282261
Source
Int J Cancer. 2017 Feb 01;140(3):581-590
Publication Type
Article
Date
Feb-01-2017
Author
Myeongjee Lee
Marie Reilly
Linda Sofie Lindström
Kamila Czene
Source
Int J Cancer. 2017 Feb 01;140(3):581-590
Date
Feb-01-2017
Language
English
Publication Type
Article
Keywords
Female
Humans
Male
Middle Aged
Mothers
Neoplasms - mortality
Proportional Hazards Models
Registries
Risk factors
Siblings
Sweden
Abstract
Family history of cancer is a well-known risk factor but the role of family history in survival is less clear. The aim of this study was to investigate the association between family history and cancer survival for the common cancers in Sweden. Using the Swedish population-based registers, patients diagnosed with the most common cancers were followed for cancer-specific death during 1991-2010. We used multivariate proportional hazards (Cox) regression models to contrast the survival of patients with a family history of cancer (individuals whose parent or sibling had a concordant cancer) to the survival of patients without a family history. Family history of cancer had a modest protective effect on survival for breast cancer (hazard ratio (HR)?=?0.88, 95% confidence interval (95% CI)?=?0.81 to 0.96) and prostate cancer (HR?=?0.82, 95% CI?=?0.75 to 0.90). In contrast, family history of cancer was associated with worse survival for nervous system cancers (HR?=?1.24, 95% CI?=?1.05 to 1.47) and ovarian cancer (HR?=?1.20, 95% CI?=?1.01 to 1.43). Furthermore, the poorer survival for ovarian cancer was consistent with a higher FIGO stage and a greater proportion of more aggressive tumors of the serous type. The better survival for patients with a family history of breast and prostate cancer may be due to medical surveillance of family members. The poor survival for ovarian cancer patients with an affected mother or sister is multifactorial, suggesting that these cancers are more aggressive than their sporadic counterparts.
PubMed ID
27759937 View in PubMed
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