[Wegener's granulomatosis. New aspects of diagnosis, treatment and prognosis].

https://arctichealth.org/en/permalink/ahliterature228361
Source
Tidsskr Nor Laegeforen. 1990 Sep 20;110(22):2881-4
Publication Type
Article
Date
Sep-20-1990
Author
H J Haga
D. D'Cruz
G. Hughes
Author Affiliation
Rayne Institute, St. Thomas Hospital, London.
Source
Tidsskr Nor Laegeforen. 1990 Sep 20;110(22):2881-4
Date
Sep-20-1990
Language
Norwegian
Publication Type
Article
Keywords
Adult
Aged
Female
Humans
Male
Norway
Prognosis
Wegener Granulomatosis - diagnosis - drug therapy - mortality
Abstract
In its classical form, Wegener's granulomatosis (WG) is characterized by acute granulomatous vasculitis of the upper and lower respiratory tract together with glomerulonephritis, and when untreated, mortality is high. The use of cyclophosphamide and prednisolon has improved the prognosis dramatically, while azathioprine and trimetoprim-sulfamethoxazole are of limited therapeutic value in these patients. Only 1/3 of subacute and chronic cases show renal impairment, and the prognosis is better in limited Wegener's granulomatosis without renal disease than in the classical form. This case-report and review takes up various new aspects of diagnosis, treatment and prognosis.
PubMed ID
2219066 View in PubMed
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