Hay fever--a Finnish nationwide study of adolescent twins and their parents.

https://arctichealth.org/en/permalink/ahliterature204165
Source
Allergy. 1998 Sep;53(9):885-90
Publication Type
Article
Date
Sep-1998
Author
M. Räsänen
T. Laitinen
J. Kaprio
M. Koskenvuo
L A Laitinen
Author Affiliation
Department of Medicine, Helsinki University Central Hospital, Finland.
Source
Allergy. 1998 Sep;53(9):885-90
Date
Sep-1998
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Diseases in Twins - epidemiology - genetics
Family Health
Female
Finland - epidemiology
Health Surveys
Humans
Incidence
Male
Parents
Questionnaires
Rhinitis, Allergic, Seasonal - epidemiology - genetics
Risk factors
Twins, Dizygotic - genetics
Twins, Monozygotic - genetics
Abstract
Like other atopic diseases, hay fever is known to cluster in families. This clustering is due either to effects of a shared family environment or to genetic inheritance. By comparing the occurrence of hay fever among monozygous (MZ) and dizygous (DZ) twin pairs, we were able to estimate the contribution of genetic and environmental factors in the development of hay fever.
A questionnaire mailed to a nationwide sample of 2483 families with 16-year-old twins furnished data for the cumulative incidence of physician-diagnosed hay fever among these adolescents and their parents.
Among the 1765 twin pairs with data available for analysis, hay fever was reported for 14.1% of boys (95% CI=12.4-15.8%) and 10.0% of girls (95% CI=8.6-11.4%). The MZ twin pairs (probandwise concordance rate=60.3%, 95% CI =52-68%) were significantly more concordant for hay fever than were DZ twin pairs (31.5%, 95% CI=26-36%). Genetic factors accounted for 74-82% of the interindividual variability in liability to hay fever, variation in shared family environment for 7% at most, and unique (individual) environment for 18%.
Familial occurrence of hay fever is mainly due to genes predisposing to the trait. Environmental exposures shared in common by family members but varying between families appear to account for at most a modest proportion of the variability in risk of developing hay fever.
PubMed ID
9788691 View in PubMed
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