A sequence variation in the mitochondrial glycerol-3-phosphate dehydrogenase gene is associated with increased plasma glycerol and free fatty acid concentrations among French Canadians.

https://arctichealth.org/en/permalink/ahliterature195413
Source
Mol Genet Metab. 2001 Mar;72(3):209-17
Publication Type
Article
Date
Mar-2001
Author
J. St-Pierre
M C Vohl
D. Brisson
P. Perron
J P Després
T J Hudson
D. Gaudet
Author Affiliation
Dyslipidemia, Diabetes and Atherosclerosis Research Group, Chicoutimi Hospital, Quebec, Canada.
Source
Mol Genet Metab. 2001 Mar;72(3):209-17
Date
Mar-2001
Language
English
Publication Type
Article
Keywords
Adult
Aged
Base Sequence
Canada
Diabetes Mellitus, Type 2 - genetics
Fatty Acids, Nonesterified - blood
France - ethnology
Genetic Variation
Glycerol - blood
Glycerolphosphate Dehydrogenase - genetics
Humans
Male
Middle Aged
Mitochondria
Reference Values
Abstract
FAD-dependent glycerol-3-phosphate dehydrogenase (mGPD) enzyme is located in the mitochondrial inner membrane where it catalyzes irreversible oxidation reactions. Type 2 diabetes mellitus (DM) is a multifactorial disorder associated with physiological abnormalities in the glycerol and free fatty acids (FFA) metabolic pathways. In the present study, we have evaluated the association among the mGPD H264R sequence variation and postabsorptive plasma FFA and glycerol concentrations in a sample of French Canadians with and without type 2 DM. A sample of 81 recently diagnosed type 2 DM and 318 nondiabetic, nonobese, normotriglyceridemic French Canadians were screened for the presence of the mGPD H264R genetic variant using a PCR-RFLP-based method. The 318 nondiabetic subjects were free of known type 2 DM covariates (fasting glucose
PubMed ID
11243726 View in PubMed
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