Southwestern Athabaskan (Navajo and Apache) genetic diseases.

https://arctichealth.org/en/permalink/ahliterature195294
Source
Genet Med. 1999 May-Jun;1(4):151-7
Publication Type
Article
Author
R P Erickson
Author Affiliation
Steele Memorial Children's Research Center, Department of Pediatrics, University of Arizona College of Medicine, Tucson, USA. erickson@peds.arizona.edu
Source
Genet Med. 1999 May-Jun;1(4):151-7
Language
English
Publication Type
Article
Keywords
Brain Stem - abnormalities
Canada
Evolution, Molecular
Genes, Recessive
Genetic Diseases, Inborn - epidemiology - ethnology
Genetic Linkage
Genetic Predisposition to Disease
Humans
Indians, North American
Severe Combined Immunodeficiency - epidemiology - genetics
Skin Diseases - epidemiology - genetics
United States
Abstract
Four apparently unique disorders are known among the Southwestern Athabasan Amerindians, i.e., the Navajo and Apache; they are Athabaskan severe combined immunodeficiency, Navajo neuropathy, Navajo poikiloderma, and Athabaskan brainstem dysgenesis. This study reviews background information on Athabaskan groups and clinical descriptions of these recessive disorders.
The major clinical findings of these four disorders are reviewed. In addition, the findings of epidemiological surveys are included where available.
Although the importance of genetic bottlenecks in increasing the frequency of rare, sometimes unique, autosomal recessive disorders is known for a number of populations, similar phenomena among Native Americans seem to be less well known.
As many more Native Americans move off the Reservation, the awareness of susceptibility to particular genetic diseases needs to be more widely disseminated.
Notes
Comment In: Genet Med. 1999 Sep-Oct;1(6):30511258633
PubMed ID
11258351 View in PubMed
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