[Distribution of structural polymorphisms of angiotensin-converting enzyme and serotonin receptor 5-HT2A genes among long-livers of North-Western Russia].

https://arctichealth.org/en/permalink/ahliterature138283
Source
Adv Gerontol. 2011;24(4):620-5
Publication Type
Article
Date
2011
Author
T Iu Smirnova
D L Spivak
G S Iakupova
A G Zakharchuk
I M Spivak
Source
Adv Gerontol. 2011;24(4):620-5
Date
2011
Language
Russian
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Blood Pressure - genetics
Depression - genetics - metabolism
Female
Gene Frequency
Genome-Wide Association Study
Humans
Male
Middle Aged
Peptidyl-Dipeptidase A - genetics
Polymorphism, Genetic
Receptors, Serotonin, 5-HT2 - genetics
Renin-Angiotensin System - genetics
Russia
Serotonin - metabolism
Synaptic Transmission - genetics
Abstract
In the group of long-livers of the North-West of Russia, I/D polymorphism of angiotensin-converting enzyme (ACE) gene and C102T polymorphism of serotonin receptor (5-HT2A) gene were studied. No reliable differences in allele frequency of these genes between long-livers and young people were detected. Nevertheless, highly pronounced difference in the A1/A2 allele frequency of 5-HT2A gene between populations of the North-West of Russia, on the one hand, and of the USA, on the other hand, was discovered (i.e. 0.397(A1), 0.603(A2), and 0.615(A1), 0.385(A2), respectively). Differences of this kind between the two populations deserve special consideration, conditioning the necessity of further detailed analysis of other genes of the serotonin system in the populations of other regions of Russia.
PubMed ID
22550870 View in PubMed
Less detail