Toxoplasma infection and later development of schizophrenia in mothers.

https://arctichealth.org/en/permalink/ahliterature134847
Source
Am J Psychiatry. 2011 Aug;168(8):814-21
Publication Type
Article
Date
Aug-2011
Author
Marianne Giørtz Pedersen
Hanne Stevens
Carsten Bøcker Pedersen
Bent Nørgaard-Pedersen
Preben Bo Mortensen
Author Affiliation
National Center for Register-Based Research, Aarhus University, Denmark. mgp@ncrr.dk
Source
Am J Psychiatry. 2011 Aug;168(8):814-21
Date
Aug-2011
Language
English
Publication Type
Article
Keywords
Adult
Cohort Studies
Cross-Sectional Studies
Denmark
Female
Follow-Up Studies
Humans
Immunoglobulin G - blood
Infant, Newborn
Male
Neonatal Screening
Pregnancy
Pregnancy Complications, Parasitic - diagnosis - epidemiology - immunology - psychology
Prospective Studies
Risk
Schizophrenia - diagnosis - epidemiology - immunology
Toxoplasma - immunology
Toxoplasmosis - diagnosis - epidemiology - immunology - psychology
Toxoplasmosis, Congenital - diagnosis - epidemiology - immunology - psychology
Young Adult
Abstract
Several studies based on clinical samples have found an association between Toxoplasma gondii infection and schizophrenia, and a case-control study among U.S. military personnel with specimens available from both before and after diagnosis found a positive association between T. gondii immunoglobulin G (IgG) antibody level and schizophrenia. These findings have never been replicated in a prospective cohort study. The purpose of this study was to determine whether mothers infected with T. gondii have an elevated risk of schizophrenia or related disorders and whether the risk depends on IgG antibody level.
In a register-based prospective cohort study of 45,609 women born in Denmark, the level of T. gondii-specific IgG antibodies was measured in connection with childbirth between 1992 and 1995. Women were followed up from the date of delivery until 2008.
A significant positive association between T. gondii IgG antibody level and schizophrenia spectrum disorders was found. Mothers with the highest IgG level had a relative risk of 1.73 (95% confidence interval [CI]=1.12-2.62) compared with mothers with the lowest IgG level. For schizophrenia, the relative risk was 1.68 (95% CI=0.77-3.46). When the mothers were classified according to IgG level, only those with the highest IgG levels had a significantly higher risk of schizophrenia spectrum disorders.
Women with high levels of T. gondii-specific IgG antibodies have a significantly elevated risk of developing schizophrenia spectrum disorders.
Notes
Comment In: Am J Psychiatry. 2011 Aug;168(8):764-621813490
PubMed ID
21536690 View in PubMed
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