Endothelial function and circulating biomarkers are disturbed in women and children after preeclampsia.

https://arctichealth.org/en/permalink/ahliterature134259
Source
Hypertension. 2011 Jul;58(1):63-9
Publication Type
Article
Date
Jul-2011
Author
Anne Stine Kvehaugen
Ralf Dechend
Heidi Bente Ramstad
Rebecca Troisi
Drude Fugelseth
Anne Cathrine Staff
Author Affiliation
Department of Obstetrics and Gynecology, Oslo University Hospital, Ulleval, Oslo, Norway.
Source
Hypertension. 2011 Jul;58(1):63-9
Date
Jul-2011
Language
English
Publication Type
Article
Keywords
Adult
Biological Markers - blood
Cardiovascular Diseases - blood - epidemiology - physiopathology
Child
Child, Preschool
Endothelium, Vascular - physiopathology
Female
Follow-Up Studies
Humans
Incidence
Norway - epidemiology
Postpartum Period - physiology
Pre-Eclampsia - blood - physiopathology
Pregnancy
Prognosis
Retrospective Studies
Risk factors
Vascular Resistance - physiology
Abstract
Preeclampsia is a long-term cardiovascular risk factor for the mother and possibly the offspring. Preeclampsia and cardiovascular diseases share common pathophysiological features, including endothelial dysfunction. We explored whether endothelial function, measured noninvasively, as well as circulating biomarkers reflecting lipid metabolism, angiogenesis, and inflammation, differed in paired mothers and offspring 5 to 8 years after delivery. Twenty-six mother and child pairs after pregnancies complicated by preeclampsia were compared with 17 mother and child pairs after uncomplicated pregnancies. In addition, we assessed whether concentrations of maternal circulating biomarkers at delivery predicted findings 5 to 8 years postpartum. We also included an assessment of early onset preeclampsia and specifically addressed the effects of small for gestational age. Endothelial function was significantly reduced in both mothers and children after preeclampsia when combined with a small-for-gestational-age infant compared with mothers and children after pregnancies without a small-for-gestational-age infant (mothers: P
PubMed ID
21606387 View in PubMed
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