High prevalence of abdominal aortic aneurysms in brothers and sisters of patients despite a low prevalence in the population.

https://arctichealth.org/en/permalink/ahliterature126085
Source
J Vasc Surg. 2012 Aug;56(2):305-10
Publication Type
Article
Date
Aug-2012
Author
Anneli Linné
David Lindström
Rebecka Hultgren
Author Affiliation
Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden. anneli.linne@sodersjukhuset.se
Source
J Vasc Surg. 2012 Aug;56(2):305-10
Date
Aug-2012
Language
English
Publication Type
Article
Keywords
Aged
Aortic Aneurysm, Abdominal - epidemiology - genetics - ultrasonography
Female
Humans
Male
Mass Screening
Middle Aged
Prevalence
Risk factors
Siblings
Smoking - epidemiology
Sweden - epidemiology
Abstract
Population-based screening for abdominal aortic aneurysms (AAAs) in elderly men is organized in many regions and countries in the Western world, and the prevalence of disease is reported to decline. Whether the prevalence among those with a family history also is declining is unknown. The primary purpose of this study was to assess the prevalence of AAAs among siblings of persons with AAAs and to investigate the proportion of siblings already diagnosed by opportunistic screening.
Patients treated for AAAs from January 2008 through December 2010 (n = 412) in Stockholm, Sweden, were screened for siblings. Seven hundred seventy-nine siblings were identified. All siblings 65 (odds ratio, 10.8; 95% confidence interval, 1.3-86.4; P = .03). Ever smoking was not statistically significant as a risk.
A strikingly high prevalence of AAAs in siblings was found as compared to the reported declining aneurysm prevalence in elderly men in the Western world. Systematic improvements regarding screening of first-degree relatives is mandated and selective screening of siblings is an underused tool to prevent death from aneurysm disease, both among men and women.
PubMed ID
22425245 View in PubMed
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