Source
Scand J Public Health. 2011 Jul;39(7 Suppl):185-90
Publication Type
Article
Date
Jul-2011
Author
Kaare Christensen
Kirsten Ohm Kyvik
Niels V Holm
Axel Skytthe
Author Affiliation
The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark, Department of Clinical Biochemistry and Pharmacology and Department of Clinical Genetics, Odense University Hospital, Odense, Denmark. kchristensen@health.sdu.dk.
Source
Scand J Public Health. 2011 Jul;39(7 Suppl):185-90
Date
Jul-2011
Language
English
Publication Type
Article
Abstract
Introduction: The Danish Twin Registry (DTR) has for more than 50 years been based on surveys and clinical investigations and over the two last decades also on register linkage. Currently these two approaches are merged within Statistics Denmark. Research topics: Here we report on three major groups of register-based research in the DTR that used the uniqueness of twinning. First, we focus on the ''long-term prognosis'' of being a twin compared with being a singleton and show that Danish twins have health trajectories in adulthood similar to singletons, which is a result of interest for twins and their families as well as a test of the fetal origins hypothesis that states that fetal growth restriction has long-term health consequences. Secondly, we summarise some of the most important register-based ''classical twin studies'', e.g. heritability studies on lifespan and exceptional longevity. Finally, we illustrate how the co-twin control method in a register setting can be used to control for the effect of rearing environment and genetic factors in studies of the association between exposures and health. CONCLUSION: The spectrum of register-based twin studies is very wide and have changed in accordance with methodological and data resource developments.
PubMed ID
21775381 View in PubMed
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