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Quality of health in survivors of childhood acute myeloid leukemia treated with chemotherapy only: A NOPHO-AML study.
https://arctichealth.org/en/permalink/ahliterature99787
Source
Pediatr Blood Cancer. 2010 Dec 22;
Publication Type
Article
Date
Dec-22-2010
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Author
Lene Molgaard-Hansen
Heidi Glosli
Kirsi Jahnukainen
Marianne Jarfelt
Guðmundur K Jónmundsson
Johan Malmros-Svennilson
Karsten Nysom
Henrik Hasle
Author Affiliation
Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark.
Source
Pediatr Blood Cancer. 2010 Dec 22;
Date
Dec-22-2010
Language
English
Publication Type
Article
Abstract
BACKGROUND: More than 60% of children with acute myeloid leukemia (AML) become long-term survivors, and approximately 50% are cured with chemotherapy only. Limited data exist about their long-term morbidity and social outcomes. The aim of the study was to compare the self-reported use of health care services, health experience, social outcomes, and lifestyle behavior of AML survivors with that of their sibling controls. METHODS: This population-based study included 138 children treated for AML according to the Nordic Society of Pediatric Hematology and Oncology (NOPHO)-AML-84, -88, and -93 trials, and alive by June 30, 2007. Patients treated with hematopoietic stem cell transplantation (HSCT) or relapse were not included. Altogether, 102 (74%) survivors and 91% of their siblings completed a questionnaire. RESULTS: The median follow-up was 11 (range 4-25) years after diagnosis. AML survivors had no increased rate of hospitalization compared with sibling controls, but were more often receiving prescription drugs, especially for asthma (23% vs. 9%, P?=?0.03). Self-reported health experience was excellent or very good in 77% and comparable with that of siblings. Educational achievement, employment, and marital status were comparable in the two groups. Among surviving AML patients, 23% were current smokers and 24% of their siblings were current smokers. CONCLUSIONS: The self-reported health of children treated on NOPHO-AML protocols without HSCT was good, and their use of health care services was limited. Reported health and social outcomes were comparable to those of their siblings. Many survivors were smoking which may increase the risk of late effects. Pediatr Blood Cancer © 2010 Wiley-Liss, Inc.
PubMed ID
21181875
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