[Influence of mitochondrial antioxidant 10-(6-plastoquinonyl)decyltriphenylphosphonium on peroxidation process intensity and respiratory activity of rat isolated liver after hypothermic storage]

Author: O Iu Petrenko; I O Sosimchyk; D V Cherkashyna; O A Semenchenko; V P Skulachov

Keywords: Animals; Antioxidants - pharmacology; Cell Respiration - drug effects; Cold Temperature; Energy Metabolism - drug effects; Female; Lipid Peroxidation - drug effects; Liver - drug effects - metabolism; Mitochondria, Liver - drug effects - metabolism; Organ Culture Techniques - methods; Oxygen Consumption - drug effects; Plastoquinone - analogs & derivatives - pharmacology; Rats; Thiobarbituric Acid Reactive Substances - metabolism

Abstract: The influence of mitochondria-targeted antioxidant 10-(6-plastoquinonyl)decyltriphenylphosphonium (SkQ,) different concentrations on respiratory parameters and lipid peroxidation process intensity in the rat liver after hypothermic storage was investigated. It was shown that cold storage of isolated liver during 18 h results in accumulation of TBA-active products, increase of intensity of Fe(2+)-ascorbate induced lipid peroxidation and depression of mitochondria functional activity. SkQ1 inhibits activation of free radical processes in a dose-dependent manner and it has a positive influence on energetic coupling in mitochondria.