The article presents results of clinical and functional observations of 183 patients. The authors have studied coronary reserve features in women against age and organic pathology of the vascular-heart system. An analysis of dynamics of quantitative parameters of myocardial ischemia during hospitalization showed existence of the relation between male and female in allocation of phase repolarization changes and it is seen till 45 years. This relation is disappearing in more aged patients. Load test showed that the percent of the reached load decreased with increase in age, considerably conceding in women, quantitative changes of myocardium ischemia increased with age and with an insignificant prevalence in men. Positive test was seen with maximal frequency in patients with acute forms of IHD. An analysis of hemodynamics shifts in groups of patients with organic diseases has shown that analogical changes were with a stable orientation to decrease in election fraction.