BACKGROUND: Several studies have shown the efficacy of endocrine therapy in combination with radiotherapy in high-risk prostate cancer. To assess the effect of radiotherapy, we did an open phase III study comparing endocrine therapy with and without local radiotherapy, followed by castration on progression. METHODS: This randomised trial included men from 47 centres in Norway, Sweden, and Denmark. Between February, 1996, and December, 2002, 875 patients with locally advanced prostate cancer (T3; 78%; PSA
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Comment In: Ann Intern Med. 2009 Jun 16;150(12):JC6-619528551
Comment In: Eur Urol. 2009 May;55(5):1239-40
Comment In: Eur Urol. 2009 May;55(5):1240
Comment In: Lancet. 2009 Jan 24;373(9660):274-619091392