The results of the performed comprehensive study have allowed the authors to give a hygienic assessment of the risk from environmental lead pollution in the Yamal-Nenetsk Autonomous District. By taking into account the regional features in their studies, the authors revealed certain regularities in the formation of environmental lead pollution where, along with a tendency for ambient air pollution to rise, there was a conjugated impact on the quality of portable water on the increase of a complex environmental load. Assessing the risk from the combined action of lead, by taking into account the differences in comparative toxicity on various routes of its entrance showed that the integral daily dose of lead exceeded the permissible dose for practically all inhabited localities. To minimize the risk of environmental lead pollution to human health, the regional lead standards has been scientifically founded and recommended for the inhabited localities of the Yamal region, by keeping in mind its combined impact on the organism. When all environmental objects are polluted, human health safety may be, on lead's coming into the body via various routes and modes, afforded if the level of the metal in ambient air of 0.0002 mg/m3 and with that in the drinking water of 0.01 mg/l.