BACKGROUND: Little is known about gender differences in the response to implantable cardioverter defibrillator (ICD) therapy. We compared female and male ICD patients on anxiety, depression, health-related quality of life (HRQL), ICD concerns, and ICD acceptance. METHODS: A cohort of consecutive, surviving patients (n = 535; mean age = 61.5 +/- 14.4, 81.9% male) implanted with an ICD between 1989 and 2006 completed the Hospital Anxiety and Depression Scale, the Short-Form Health Survey (SF-36), the ICD concerns questionnaire, and the Florida Patient Acceptance Survey. RESULTS: High levels of anxiety (52% vs 34%, P 0.05). Women were more anxious (odds ratio [OR]: 2.60 [95% confidence interval (CI): 1.46-4.64], P