Last years showed allergy to be significant and social problem. Pollinosis is one of the most frequently spread allergy forms. Pollinosis presents itself in the form of allergic rhinitis, allergic conjunctivitis which may develop in bronchial asthma. Kievites pollinosis (seasonal fever) in most cases is caused by ambrosia, sunflower and dandelion pollen. Specific immunotherapy proved to be the most effective method in the treatment of patients with polinosis. It reduces symptomes of the disease, changes the natural course of the disease and helps developing in patient long-lasting immunity. Clinical follow-up during a long period of time confirmed that three-year treatment course is an optimal one to get long-lasting remission of the disease.