Two cases of infection with multiply resistant Salmonella virchow were probably acquired in Denmark. A 30-year old man and a 20-year old woman had both eaten from the same buffet at a summer restaurant and developed gastrointestinal symptoms and fever after three and six days, respectively. The patients ran a fever for two and five weeks before the admission to the hospital and the woman developed a tuboovarial abscess complicated by peritonitis. S. virchow resistant to ampicillin, streptomycin, tetracycline, and sulfonamide was isolated from faeces in the male patient and from intraabdominal pus in the female patient. Among 35 Danish S. virchow isolates from January 1 to August 31, 1992 there was only one additional multiply resistant isolate (resistant to streptomycin, tetracycline, sulfonamide, and chloramphenicol) the source of which was unknown.