As many as 350 patients with ineffective treatment of freshly detected destructive pulmonary tuberculosis were analyzed in retrospection. The following four groups of causes of ineffective treatment of these cases were identified: tardy detection and late start of the treatment (49.71%); features of the tuberculous process, the extent to which it has spread in particular; dangerous complications and intercurrent illnesses (66.57%); a not-rational treatment of a patient with tuberculosis (85.14%); untimely discontinuance of treatment (38.86%). In a major proportion of patients these causes tended to be combined, which fact is to be kept in mind in one's daily work for such causes to be cleared away.