The number of suicides in Norway has doubled during the last two decades, as has also the number of suicides by intoxication. Data are presented which demonstrate that while barbiturates make out a strongly decreasing percentage of the intoxications, the antidepressants make out a definite increasing percentage. The tricyclic antidepressants make out the bulk. There is a strong need for effective antidepressants with less toxicity than the commonly used tricyclic antidepressants.