Biochemical composition of the bile and blood serum was investigated in Evenkia and Yakutia residents and immigrants. Blood lipids in the immigrants were much higher while bile lipids lower than in the natives. It is suggested that normolipidemia in the residents may be determined by intensive synthesis of biliary acids and other lipids in the liver and their secretion into the bile. Later, high content of primary cholates (17%) was found in the bile of residents which was not confirmed in the immigrants.