Low pulse-wave amplitude during reactive leg hyperaemia: an independent, early marker for ischaemic heart disease and death. Results from the 21-year follow-up of the prospective cohort study 'Men born in 1914', Malmö, Sweden.
OBJECTIVE. To study the incidence of myocardial infarction, all-cause mortality and mortality from ischaemic heart disease in relation to arterial leg blood flow determined by venous occlusion plethysmography of the calf. DESIGN. A prospective cohort study 'Men born in 1914'. SETTING. Malmö, a city in southern Sweden with 256,000 inhabitants, and a single referral hospital. SUBJECTS. Six-hundred and thirty-six 55-year-old men, randomly selected from the general population. None of them had signs or symptoms of leg artery disease. MAIN OUTCOME MEASURES. All-cause mortality, morbidity and mortality from ischaemic heart disease during 21 years of follow-up following the initial examination in 1968. RESULTS. A low pulse-wave amplitude (i.e.