With the purpose of detecting long-term somatic effects of incorporated iodine, an analysis was performed of health disorders in those subjects (n = 1040) who received 131 I in therapeutic dosages 25 to 30 years ago. Discordances in pituitary-thyroid- and pituitary-adrenal axes were found to result in excessive metabolic-degenerative and vegetovascular type morbidity rates compared with the general population. Mortality index exceeds that of in the population 2.1-fold. No one of the deceased had reached the average length of human life. Halt the cases died of ischemic heart disease, 6 patients developed carcinoma of endocrine organs; these were all females, who had taken radioactive iodine prior to the age of 30 years. Thus, in remote time periods after incorporation, there develop a number of those disorders leading ultimately to reduction of the length of human life, which is believed to be one of the universal effects of irradiation.