Mycologic examinations of patients with mycoses of the soles, working at 5 metallurgical plants in the town of Zaporozhye, have detected T. rubrum in 71.3 percent and T. interdigitale in 28.7 percent of cases. In 110 (18.3 percent) patients C. albicans were isolated from foci of involvement in parallel with Trichophyton. As a rule these patients were engaged in 'hot' shops and suffered from dysfunctions of various vital organs and from metabolic disorders. Mycoses of the soles complicated with Candida infection were characterized by marked exudation and dissemination with symptoms of eczema, intensive itching, efflorescence of the allergic type. High immediate and delayed-type hypersensitivity to administration of Candida antigen was observed in them. Cell-mediated and humoral immune response of these patients was essentially uncoordinated with depression of the T-immunity and nonspecific defense factors as a rule.