In the animal experiments (rabbits), a reaction was studied of lysosomal apparatus of the peripheral blood and haemostatic system neutrophilic leucocytes in response to exposure to immobilization stress under depression of thyroid system caused by administration of mercazolilum. Thyroid hormones were ascertained to play their part in regulation of functional activity of Hageman-dependent systems of blood via activation of lysosomal apparatus of neutrophilic leucocytes of the rabbits' blood.